Generic Formulary
Genito Urinary System
Sub Group: 
International Brand Name: 
250 MG
Unit of Packing: 
In treatment of: 
Induction of Diuresis
Adverse Effects: 
1.Numbness and tingling in fingers 2.Taste disturbances 3.Hypokalemia 4.Acidosis 5.Blurred vision 6.Headache 7.Drowsiness 8.Paresthesia 9. Fatigue 10.Abdominal discomfort 11.Nausea 12.Fever 13.Rashes 14.Allergic reactions 15.Bone marrow depression(rare) 16.Ototoxicity
1.Hypersensitivity to the drug 2.Hyponatremia 3.Hypokalemia 4.Renal impairment 5.Hepatic impairment 6.Adrenal insufficiency 7.Long term management of non congestive chronic angle closure glaucoma 8.Hyperchloremic acidosis.
Special Precaution: 
1.Diabetes mellitus 2.Sickle cell anaemia 3.Gout 4.Hypesensitivity to Sulfonamides 5.Chronic obstructive pulmonary disorders 6.Emphysem 7.Respiratory acidosis 8.Along with other diuretics
Amphetamine, Ephedrine, Flecainide, Pseudoephedrine, Quinidine: Potentiates effect by decreasing their renal excretion. Digitalis: Digitals toxicity since it induces hypokalemia Primidone: May delay absorption. Salicylates: Salicylate toxicity due to metabolic acidosis. Corticosteroids: Hypokalemia. Lithium: Efficacy diminished. Sulfonamides: Aids penetration across Blood/CSF barrier. Folic acid antagonists, Oral hypoglycaemic agents, Mercurial diuretics and Oral anticoagulants: May potentiate effect. Lab Test: Urinary Proteins Determination - False positive results.
Glaucoma: 250mg 1 to 4 times daily Epilepsy: Adults & Children: 8 to 30mg/kg/day in 2 to four divided doses. Edema in heart failure: 250 to 375mg daily in the morning Children: 5mg/kg/day orally or I.V. in the morning. Acute mountain sickness: 250 mg 2 to 3 times daily or 500mg extended release formulation twice daily take 48 hours before ascent and continue until 48 hours after arrival at high altitude.

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