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Chlorpromazine
Product:
Chlorpromazine
Formulary:
Generic Formulary
Category:
Central Nervous System
Sub Group:
Anti Psychotics
International Brand Name:
Thorazine
Dosages:
25 MG/50 mg/100mg
Unit of Packing:
Tablets
In treatment of:
Mgt of Psychiatric conditions
Adverse Effects:
.Tardive dyskinesia
2.Extrapyramidal reactions
3.Drowsiness
4.Sedation
5.Dizziness
6.Hypotension
7.Dry mouth
8.Constipation
9.Blurred vision
10.Agranulocytosis
11.Photosensitivity
12.Insomnia
13.Urine retention
14.Cholestatic jaundice
15.Aplastic anaemia
16.Pain at injection site.
Contraiindication:
1.Hypersensitivity to Chlorpromazine and other Phenothiazines
2.Comatose
3.Bone marrow depression
4.Depression
Special Precaution:
1.Renal impairment
2.Hepatic impairment
3.Cardiovascular disease
4.Glaucoma
5.Hypocalcaemia
6.Epilepsy
7.Respiratory disorder
8.Prostatic hyperplasia
9.Ceribrovascular disorder
10.Patient on ECT
11.Reaction to Insulin
12.Patient exposed to extreme heat or cold or phosphorus insecticides
13.Slowly withdraw the drug with caution
Interaction:
Alcohol: CNS depression, extrapyramidal reactions.
Aluminium salts: Decrease efficacy. Antacids should be given 1 hour before or 2 hours after chlorpromazine administration.
Anticholinergics: Decrease efficacy and increase the anticholinergic side effects of chlorpromazine.
Barbiturates: Decreases efficacy.
Barbiturate anaesthetics: Increase frequency and severity of neuromuscular excitation and hypotension.
Bromocriptine: Efficacy decreased by chlorpromazine.
Charcoal: Prevents absorption of chlorpromazine.
Epinephrine, Norepinephrine: Pressor effect decreased, peripheral vasoconstrictive effect antagonised.
Lithium: Disorientation, unconsciousness and extrapyramidal symptoms.
Meperidine: Excessive sedation and hypotension.
TCAs: Serum concentration increased by chlorpromazine.
Valproic acid: Efficacy potentiated.
Propranolol: Increased plasma levels of both drugs.
MAOIs: Additive orthostatic hypotensive effect.
Lab. Tests: Pregnancy tests: False positive results.
Plasma bound iodine (PBI): Increase in PBI occurs.
Servings:
Adult:
Psychoses: 25 mg 3 times a day. Dose can be gradually increased up to 800 mg / day
Maintenance dose: 75 - 300 mg / day in 3 divided doses
Nausea and vomiting: 40 - 100 mg / day in 4 divided doses. Dose can be increased if necessary.
Relief of apprehension and restlessness before surgery: 25 - 50 mg given 2 - 3 hour before surgery. If necessary the drug can be given during surgery dose is 12.5 mg as IM injection.
Acute intermittent Porphyria, Intractable hiccups: 25 - 50 mg every 6 - 8 hourly
Migraine: 12.5 mg as IV and is repeated every 20minutes up to 37.5 mg
Children:
Behavioral problems in children: 0.55 mg/ kg/ dose 4 - 6 times a day. Dose can be increased depending on the severity of patient`s condition
