Generic Formulary
Sub Group: 
International Brand Name: 
Unit of Packing: 
In treatment of: 
treatment of type Diabetes Mellitus
Adverse Effects: 
1.Hypoglycaemia 2.Nausea 3.Vomiting 4.Diarrhoea 5.Constipation 6.Headache 7.Presthesia 8.Weight gain 9.Hypersensitivity reactions 10.Rashes 11.Photosensitivity 12.Purpura 13.Transient leucopenia 14.Agranulocytosis 15.Cholestatic jaundice 16.Dilutional hyponatraemia 17.Alcohol intolerance.
1.Hypersensitivity to the drug 2.Type1 diabetes mellitus 3.Diabetes that can be adequately controlled by diet 4.Infection 5.Stress 6.Hepatitis 7.Cirrhosis 8.Alcoholics 9.Cardiac disease 10.Renal impairment
Special Precaution: 
1.Hepatic impairment 2.Cardiac failure 3.Respiratory failure 4.Ischaemic vascular disease 5.Pancreatitis 6.Porphyria 7.Malnourished individuals
Alcohol: Dilsulfiram like reaction - flushing of face and neck region. Androgens, Anticoagulants, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, Urinary acidifiers: Enhance the hypoglycemic effect of chlorpropamide due to various mechanisms. Beta-Blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalizers: Decrease hypoglycemic effect of chlorpropamide due to various mechanisms. Charcoal: Reduces the absorption of chlorpropamide leading to decrease in efficacy or toxicity. Digitalis Glycosides: Increase serum levels.
Oral: Starts with 100 to 250mg once daily with breakfast or in divided doses; if gastrointestinal disturbances occur. Adjust the dosage by increments of 50 to 125mg daily at every 3 to 5 days. Maximum dose: 500mg/day

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Kayem Pharma

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