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Clomipramine
Product:
Clomipramine
Formulary:
Generic Formulary
Category:
Central Nervous System
Sub Group:
Anti Depressants
International Brand Name:
Anafranil
Dosages:
10 MG/25 MG/50MG/75 MG
Unit of Packing:
Tablets
In treatment of:
Treatment of depression
Adverse Effects:
1.Drowsiness
2.Dizziness
3 Nausea
4.Vomiting
5.Blurred vision
6.Difficulty in micturition
7.Tachycardia
8.Hypotension
9.Arrhythmia
10. Dryness of mouth
11.Constipation
12.Confusion
13.Headache
14.Sedation
15.Agranulocytosis
16.Urticaria
17.Rash
18.Jaundice
19.Anorexia
20. Impotence
21.Loss of libido
22.Galactorrhea
23.Gynecomastia
Contraiindication:
1.Hypersensitivity to Clomipramine
2.Myocardial infarction
3.Epilepsy
4.Severe liver disease.
Special Precaution:
1.Hepatic impairment
2.Cardiac arrhythmia
3.Myocardial infarction
4.Renal impairment
5.Heart failure
6.Strokes
7.Angle closure glaucoma
8.History of urine retention
9.Hyperthyroidism
10.Alcoholics
11.Slowly withdraw the drug with caution
12.Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment
13.Tachycardia
Interaction:
Anticholinergics: Enhanced effect of anticholinergics may occur.
Barbiturates: Serum level of imipramine decreased; additive respiratory depressant effect.
Clonidine: Hypertensive crisis.
Dicoumarol: Increase in anticoagulation effects.
Disulfiram: Acute organic brain syndrome.
Fluoxetine & Haloperidol: Potentiate action of Clomipramine.
Levodopa: Its bioavailability is reduced, hypertensive episodes.
MAOIs, Furazolidone: Seizures, sweating, coma, hyperexcitability, hyperthermia, tachycardia, mydriasis, confusion, DIC (Disseminated Intravascular Coagulation) and death.
Oral Contraceptives and Phenothiazines: Increase plasma levels of Clomipramine.
Smoking: Increases metabolic bio-transformation.
Alcohol: Sedative effect of alcohol potentiated.
Servings:
Adult:
Depression: Initial dose: 10 mg at night. Dose can be gradually increased to 150 mg / day at night or in 3 - 4 divided doses.
Maintenance dose: 30 - 50 mg daily
Maximum dose: 250 mg / day
Obsessive compulsive disorder:
Initial dose: 25 mg at night. Dose can be gradually increased to 150 mg / day at night or in 3 - 4 divided doses.
