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Fosphenyton
Product:
Fosphenyton
Formulary:
Generic Formulary
Category:
Central Nervous System
Sub Group:
Anti Convulsants
Dosages:
2 ML/10 ml
Unit of Packing:
vial
In treatment of:
Treatment of tonic-clonic status Epilepticus
Adverse Effects:
1.Nystagmus
2.Dizziness
3.Ataxia
4.Pruritis
5.Somnolence
6.Headache
7.Nausea
8.Vomiting
9.Tremor
10.Incoordination
11.Heart failure
12.Paresthesia
13.Dry mouth
14.Rash
15.Dermatitis
16.Abdominal discomfort
17.Constipation
18.Anorexia
Contraiindication:
1.Hypersensitivity to the Fosphenytoin and other Hydantoins
2.Atrioventricular block
3.Sinus Bradycardia
4.Sino Atrial block
5.Adams-Stokes syndrome
Special Precaution:
1.Hepatic impairment
2.Myocardial infarction
3.Hypotension
4.Renal impairment
5.Diabetic mellitus
6.Hypoalbuminemia
7.Porphyria
Servings:
Adults: IV/IM
Status epilepticus:
Loading dose: (IV) 15 - 20 mg Phenytoin sodium equivalent (PE)/kg
Infusion rate: 100 - 150 mg / minute
Maintenance dose: 4 - 6 mg PE /kg/day
Prevention and treatment of seizure during neurosurgery:
Loading dose: (IV/IM) 10 - 20 mg Phenytoin sodium equivalent (PE)/kg
Infusion rate below 150 mg / minute
Maintenance dose: 4 - 6 mg PE /kg/day
Short term substitution for oral Phenytoin therapy:
Total oral Phenytoin sodium daily dose (200 - 400 mg / day) is given as single IM or IV at an infusion rate below 150 mg / minute
