Generic Formulary
Sub Group: 
International Brand Name: 
Glyburide,Diabeta, Glynase,micronose, Daonil, Semi-Daonil,Euglucon
2.5 MG/ 5 mg
Unit of Packing: 
In treatment of: 
treatment of type Diabetes Mellitus
Adverse Effects: 
1. Hypoglycemia 2. Nausea 3. Vomiting 4. Diarrhoea 5. Constipation 6. Headache 7. Presthesia 8. Weight gain 9. Hypersensitivity reactions 10. Rashes 11. Photosensitivity 12. Purpura 13. Transient leucopenia 14. Agranulocytosis
1. Hypersensitivity to the drug 2. Diabetic ketoacidosis 3. Diabetic coma 4. Renal impairment
Special Precaution: 
1. Hepatic impairment 2. Malnourished and deliberate individuals 3. Strenous exercise and irregular meals may leads to hypoglycemia
Hypoglycaemic effect of glibenclamide is enhanced by: Anticoagulants, Androgens, Chloramphenicol, Clofibrate, Fenfluramine, Fluconazole, Gemfibrozil, Histamine H2 antagonists, Magnesium Salts, Methyldopa, MAOIs, Phenylbutazone, Probenecid, Salicylates, Sulfinpyrazone, Sulfonamides, TCAs, & Urinary acidifiers. Hypoglycemic effect of glibenclamide inhibited by the following drugs: Beta-blockers, Cholestyramine, Diazoxide, Hydantoins, Rifampicin, Thiazide diuretics & Urinary alkalisers. Charcoal: Reduces the absorption of glibenclamide thus reducing its efficacy or toxicity. Digitalis glycosides: Co-administration results in increased digitalis serum levels.
Oral: Starts with 2.5mg once daily with breakfast. Adjust the dosage by increments of 2.5mg daily. Maximum dose: 15mg/day Maintenance dosage: 1.25 to 15mg once daily with breakfast or in divided doses; if gastrointestinal disturbances occur.

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