Generic Formulary
Cardio Vascular System
Sub Group: 
International Brand Name: 
12.5 MG/25 Mg
Unit of Packing: 
In treatment of: 
Treatment of Oedema associated w/ heart failure
Adverse Effects: 
1. Dizziness 2. Blurred vision 3. Confusion 4. Tingling fingers 5. Dry mouth 6. Nausea 7. Diarrhoea 8. Constipation 9. Vomiting 10. Weakness 11. Hypokalaemia 12. Hyponatraemia 13. Hyperuricaemia 14. Elevated levels of glucose, calcium and lipids 15. Gastro intestinal disturbances 16. Polyuria 17. Electrolyte imbalance 18. Jaundice 19. Rashes 20. Photosensitivity 21. Fever 22. Itching 23. Myalgia 24. Muscle cramps 25. Arthralgia 26. Blood dyscrasias 27. Ototoxicity
1. Hyper uricaemia 2. Hyper calcaemia 3. Renal impairment 4. Hepatic impairment 5. Anuria 6. Hypersensitivity to the drug 7. Hyper sensitivity to sulfonamides 8. Fluid and electrolyte imbalance
Special Precaution: 
1. Gout 2. Diabetes mellitus 3. Renal impairment 4. Hepatic impairment 5. Monitor and correct Fluid and electrolyte imbalance 6. Hyper parathyroidism 7. Cirrhosis
Cholestyramine & Colestipol: decrease absorption of hydrochlorothiazide. Diazoxide: Additive action - may cause hyperglycemia, hyperuricaemia and hypotension. Digitalis: Diuretics induced hypokalaemia may precipitate digitalis toxicity. Lithium: Hydrochlorothiazide potentiates therapeutic and toxic effects by increasing its renal excretion. Frusemide: Synergy leading to profound diuresis and greater than predicted electrolyte loss. Non-depolarizing muscle relaxants: Diuretics induced hypokalaemia enhances efficacy. Sulfonylureas: Efficacy decreased due to hydrochlorothiazide induced glucose intolerance. Chlorpropamide: Hypokalaemia. Propantheline: Bioavailability of hydrochlorothiazide increased. Metoclopramide: Bioavailability of hydrochlorothiazide decreased. NSAIDs: Natriuretic effect of hydrochlorothiazide decreased.
Adults: Hypertension: 25mg once daily or in divided doses. Increased to 50mg if required; depending up on the patient`s response. Children: 1mg/kg single daily dose. Oedema: Adults: Starts with 25 to 50mg. Increased the dose until desired response is obtained. Maximum dose: 200mg/day Maintenance dosage: 25 to 100mg daily or on alternate days. Children: 1mg/kg single daily dose or 1 to 3mg/kg/day in two divided doses

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