LERCANIDIPINE

Product: 
LERCANIDIPINE
Formulary: 
Generic Formulary
Category: 
Cardio Vascular System
Sub Group: 
ANTI HYPERTENSIVE DRUGS
International Brand Name: 
Zamidip
Dosages: 
10 MG/20 mg
Unit of Packing: 
Tablets
In treatment of: 
Management of Hyper Tension(HTN)
Adverse Effects: 
1. Flushing 2. Tachycardia 3. Palpitation 4. Hypotension 5. Edema 6. Headache 7. Dizziness 8. Vertigo 9. Drowsiness 10. Fatigue
Contraiindication: 
1. Acute myocardial infarction 2. Heart failure 3. Aortic stenosis 4. Hypersensitivity to the drug 5. Severe hepatic and renal impairment
Special Precaution: 
1.Cardiovascular disorders: Use cautiously in cardiovascular disorders such as congestive heart failure, cardiovascular insufficiency, hypotension, Ischaemic heart diseases, Left ventricular outflow obstruction, Sick sinus syndrome, Unstable angina etc. 2. Hepatic impairment 3. Renal impairment Other precautions: 1. Slowly withdraw the drug with caution 2. Avoid alcohol use during therapy 3. Use cautiously along with other antihypertensive drugs
Interaction: 
Avoid grapefruit juice as it may affect metabolism. Histamine H2 antagonists: Cimetidine and ranitidine enhance the bioavailability of lercanidipine. Beta blockers: Though advantageous in some, concomitant use results in increased adverse effects like bradycardia and conduction disturbances. Digitalis Glycosides: Increased serum digoxin levels with possible toxicity. Magnesium Sulphate: With parenteral magnesium suplhate neuromuscular blockade and hypotension may occur. Theophyllines: Increased pharmacological effects of theophylline, resulting in toxicity. Quinidine: Hypotension, bradycardia, ventricular tachycardia, AV block and pulmonary oedema may occur. Serum quinidine levels may also be decreased by lercanidipine. Anticoagulants: Increased prothrombin time. Fentanyl: Severe hypotension or increased fluid requirements.
Servings: 
10mg once daily; 15minutes before meals. Gradually increased at 2week intervals up to 20mg if required depending up on the patient`s response..

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