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RESERPINE
Product:
RESERPINE
Formulary:
Generic Formulary
Category:
Cardio Vascular System
Sub Group:
ANTI HYPERTENSIVE DRUGS
International Brand Name:
Ecoplanet,Serpazide
Dosages:
0.25 MG
Unit of Packing:
Tablets
In treatment of:
Management of Hyper Tension(HTN)
Adverse Effects:
1.Excessive salivation
2.Nasal congestion
3.Cutaneous vasodilatation
4.Increased gut motility
5.Increased acidity
6.A-V conduction blocks
7.Orthostatic hypotension
8.Mental depression
9.Exacerbate epilepsy
10.Weight gain
11.Electrolyte imbalance
12.Parkinsonism
13.Gynecomastia
14.Impotence
15.Hypotension
16.Purpura
17.Thrombocytopenia
Contraiindication:
1.Depression
2.In patients receiving electro convulsive therapy
3.Peptic ulcer
4.Ulcerative colitis
5.Parkinsonism
6.Pheochromocytoma
7.Thyrotoxicosis
Special Precaution:
1.Tachycardia
2.Myocardial infarction
3.Arrhythmia
4.Bradycardia
5.Cardiac failure
6.Renal impairment
7.Hepatic impairment
6.Epilepsy
Interaction:
Antihypertensives / Diuretics: Antihypertensive effects are enhanced.
Digitialis and Quinidine: May result in cardiac arrhythmias.
Ephedrine or Mephentermine: Hypertension may occur.
General anaesthesia: Hypotension and bradycardia may occur.
Levodopa: Signs and symptoms of Parkinsonism may be exacerbated.
MAOIs: Should be avoided since it may result in hypertension.
Sympathomimetics: Reserpine prolongs sympathomimetic response of direct acting and inhibits of indirect acting sympathomimetics.
TCAs: Results in a response refractory to TCA therapy. Also hypotension, flushing, diarrhoea and manic reactions may occur.
Lab tests: Increased serum prolactin levels, decreased urinary excretion of catecholamines, 17-ketosteroids, 17-hydroxycorticosteroids (17-OCHS) and vanillyl mandelic acid (VMA).
Servings:
250 to 500mcg/day, gradually reduce to maintenance dose of 250mcg/day
Maximum dose: 1mg to 1.5 mg
