Generic Formulary
Cardio Vascular System
Sub Group: 
International Brand Name: 
0.25 MG
Unit of Packing: 
In treatment of: 
Management of Hyper Tension(HTN)
Adverse Effects: 
1.Excessive salivation 2.Nasal congestion 3.Cutaneous vasodilatation 4.Increased gut motility 5.Increased acidity 6.A-V conduction blocks 7.Orthostatic hypotension 8.Mental depression 9.Exacerbate epilepsy 10.Weight gain 11.Electrolyte imbalance 12.Parkinsonism 13.Gynecomastia 14.Impotence 15.Hypotension 16.Purpura 17.Thrombocytopenia
1.Depression 2.In patients receiving electro convulsive therapy 3.Peptic ulcer 4.Ulcerative colitis 5.Parkinsonism 6.Pheochromocytoma 7.Thyrotoxicosis
Special Precaution: 
1.Tachycardia 2.Myocardial infarction 3.Arrhythmia 4.Bradycardia 5.Cardiac failure 6.Renal impairment 7.Hepatic impairment 6.Epilepsy
Antihypertensives / Diuretics: Antihypertensive effects are enhanced. Digitialis and Quinidine: May result in cardiac arrhythmias. Ephedrine or Mephentermine: Hypertension may occur. General anaesthesia: Hypotension and bradycardia may occur. Levodopa: Signs and symptoms of Parkinsonism may be exacerbated. MAOIs: Should be avoided since it may result in hypertension. Sympathomimetics: Reserpine prolongs sympathomimetic response of direct acting and inhibits of indirect acting sympathomimetics. TCAs: Results in a response refractory to TCA therapy. Also hypotension, flushing, diarrhoea and manic reactions may occur. Lab tests: Increased serum prolactin levels, decreased urinary excretion of catecholamines, 17-ketosteroids, 17-hydroxycorticosteroids (17-OCHS) and vanillyl mandelic acid (VMA).
250 to 500mcg/day, gradually reduce to maintenance dose of 250mcg/day Maximum dose: 1mg to 1.5 mg

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